I<span style="caret-color: rgb(69, 69, 69); color: rgb(69, 69, 69); font-family: robotoregular, Meiryo; font-size: 13px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; display: inline !important; float: none;">n order to improve bioactivity of hydroxyapatite (HA), the surface of HA was modified with calcium or magnesium ion irradiation. Calcium ion irradiation improved bioactivity of HA up to ion dose 10</span><sup style="box-sizing: border-box; line-height: inherit; position: relative; vertical-align: baseline; top: -0.5em; margin: 0px; padding: 0px; border: 0px; font-family: robotoregular, Meiryo; font-size: inherit; font-style: normal; font-variant-caps: normal; font-weight: normal; font-stretch: inherit; caret-color: rgb(69, 69, 69); color: rgb(69, 69, 69); letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">14</sup><span style="caret-color: rgb(69, 69, 69); color: rgb(69, 69, 69); font-family: robotoregular, Meiryo; font-size: 13px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; display: inline !important; float: none;"><span class="Apple-converted-space">&nbsp;</span>ions/cm</span><sup style="box-sizing: border-box; line-height: inherit; position: relative; vertical-align: baseline; top: -0.5em; margin: 0px; padding: 0px; border: 0px; font-family: robotoregular, Meiryo; font-size: inherit; font-style: normal; font-variant-caps: normal; font-weight: normal; font-stretch: inherit; caret-color: rgb(69, 69, 69); color: rgb(69, 69, 69); letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none;">2</sup><span style="caret-color: rgb(69, 69, 69); color: rgb(69, 69, 69); font-family: robotoregular, Meiryo; font-size: 13px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; text-decoration: none; display: inline !important; float: none;">, whereas magnesium ion irradiation did not affect bone-like apatite formation. It is found that this different phenomena were attributed to surface electrical potential. Ion irradiation generally induces surface nano-scopic damage, however the strength of HA was not significantly affected by ion irradiation. From cell proliferation, no toxicity of HA irradiated with calcium ions was confirmed. From these results, the effectiveness of calcium ion irradiation on the treatment of bone defect using HA is confirmed.</span>

Keywords

Hydroxyapatite, Ion irradiation, Strength, Bone-like apatite formation, Cell proliferation

Paper information

Satoshi KOBAYASHI, Tomomi IZAWA, Yoshikazu TERANISHI, Yoshimi OHYABU, “Effect of Ca or Mg ion irradiation on the bioactivity and strength of hydroxyapatite”, Journal of Biomechanical Science and Engineering, Vol.13, No.3 (2018), p.18-00036. doi.org/10.1299/jbse.18-00036. Final Version Released on November 16, 2018, Advance Publication Released on August 06, 2018.